- Title
- Targeting treatable traits in severe asthma: a randomised controlled trial
- Creator
- McDonald, Vanessa M.; Clark, Vanessa L.; Cordova-Rivera, Laura; Wark, Peter A. B.; Baines, Katherine J.; Gibson, Peter G.
- Relation
- European Respiratory Journal Vol. 55, Issue 3, no. 1901509
- Publisher Link
- http://dx.doi.org/10.1183/13993003.01509-2019
- Publisher
- European Respiratory Society
- Resource Type
- journal article
- Date
- 2020
- Description
- Rationale: Treatable traits have been proposed as a new paradigm for airway disease management. Objectives: To characterise treatable traits in a severe asthma population and to determine the efficacy of targeting treatments to these treatable traits in severe asthma. Methods: Participants (n=140) with severe asthma were recruited to a cross-sectional study and underwent a multidimensional assessment to characterise treatable traits. Eligible participants with severe asthma (n=55) participated in a 16-week parallel-group randomised controlled trial to determine the feasibility and efficacy of management targeted to predefined treatable traits, compared to usual care in a severe asthma clinic. The patient-reported outcome of health-related quality of life was the trial’s primary end-point. Main results: Participants with severe asthma had a mean±SD of 10.44±3.03 traits per person, comprising 3.01±1.54 pulmonary and 4.85±1.86 extrapulmonary traits and 2.58±1.31 behavioural/risk factors. Individualised treatment that targeted the traits was feasible and led to significantly improved health-related quality of life (0.86 units, p<0.001) and asthma control (0.73, p=0.01). Conclusions: Multidimensional assessment enables detection of treatable traits and identifies a significant trait burden in severe asthma. Targeting these treatable traits using a personalised-medicine approach in severe asthma leads to improvements in health-related quality of life, asthma control and reduced primary care acute visits. Treatable traits may be an effective way to address the complexity of severe asthma.
- Subject
- asthma; allergy; treatable traits; quality of life; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1451399
- Identifier
- uon:44178
- Identifier
- ISSN:0903-1936
- Language
- eng
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